2021 Annual Meeting

Date: October 14-16
Location: Virtual
October 15 & 16 – Scientific & Clinical Abstract Presentations (0900-1500 CDT)
October 16 – Symposium on Epilepsy and Neoplasms (0900-1400 CDT)

Purchase Tickets

Earlybird Pricing Ends Oct 1.

Preliminary Goals & Objectives
Scientific Abstract Presentations

Review of current clinical and basic science research pertaining to neuropathology with a focus on Canadian centres, but overall international participation. Also a platform for Canadian residents and trainees to present their recent work.

Diagnostic Case Presentations

Interactive discussion of rare and challenging neuropathological cases encountered by participants in their recent practice. Electronic slides and imaging results are distributed prior to meeting. Often includes case presentation by residents and illustrates advances in disease classification and diagnostic technique.

Overall learning objectives for the meeting

At the end of the meeting participants will:

  1. Describe recent developments in several areas of neuropathology with particular emphasis on the neuropathology of epilepsy and neoplasms.
  2. Discuss original research and challenging diagnostic cases with colleagues.
  3. Compare the practice of neuropathology on an individual and departmental level across Canadian centres.

Program

Please note, all times are in CDT.

0850-0900 Opening Remarks Peter Gould, CANP President
Peter Schutz, CANP Secretary-Treasurer
0900-1000 Session 1: Scientific Abstract Presentations – Neoplasms
Moderator: Dr. Peter Schutz
0900-0915 Abstract 1: Histologic and clinical spectrum of brain tumours harbouring FGFR3-TACC3 fusions F. Gianno
0915-0930 Abstract 4: Diagnostic challenges in unusual high-grade gliomas N. Sinha
0930-0945 Abstract 3: Long term disease-free survival after surgical resection only: malignant IDH-mutated astrocytoma versus ganglioglioma R. Auer
0945-1000

Abstract 2: Ganglion Cell Maturational Markers in Peripheral Neuroblastic Tumours of Children

H. Sarnat

1000-1015 Break
1015-1215 Session 2: Neuropathology Practice  I – New WHO Classification
Moderator: Dr. Peter Gould
1015-1105 Invited Lecture:
A Contemporary Molecular View of Diffuse Gliomas with Implications for Diagnosis
New WHO classification with particular emphasis on infiltrative gliomas.
Daniel Brat, MD PhD
1105-1125 Invited Lecture:
WHO 2021- Implementation in Canada
Implications of the new WHO classification for practical molecular diagnostic work with emphasis on pediatric neoplasms.
Cynthia Hawkins, MD PhD
1125-1140 Invited Lecture:
Practical impact of implementing WHO 2021 diagnostic guidelines in Canada l
Review current landscape of molecular testing for adult brain tumours and additional need to address WHO 2021 diagnostic
criteria

Stephen Yip, MD PhD
1140-1215 Panel Discussion
1215-1300 Break
1300-1430 Session 3: Scientific Abstract Presentations – Neurodegenerative and Trauma
Moderator: Dr. David Munoz
1300-1315 Abstract 5: Regional Variability of a-Synuclein Inclusion Size in Multiple System Atrophy A. Kim
1315-1330 Abstract 6: Cognitive resilience in individuals with severe Alzheimer’s disease neuropathology  N. Ahangari
1330-1345 Abstract 7: Linking iron homeostasis to vulnerability patterns in progressive supranuclear palsy  S. Lee
1345-1400 Abstract 8: Friedreich cardiomyopathy is a secondary desminopathy  A. Koeppen
1400-1415 Abstract 9: Glial senescence (not tau) is the driver of post-concussive symptoms  N. Schwab
1415-1430 Abstract 10: Hail to astrogliosis! The unsung hero of the CNS tissue reaction to the spinal cord injury.  J. Kwiecien
1430-1445 Break  
1445-1600 Session 4: Scientific Abstract Presentations – Pediatric & Epilepsy
Moderator: Dr. Leslie Hamilton
1445-1500 Abstract 11: Ischemic-like pathology in aberrant white matter tracts of fetal holoprosencephaly: a case series.  C. Dunham
1500-1515 Abstract 12: Brain pathology in patients with congenital heart disease  M.A. Alturkustani
1515-1530 Abstract 13: Characterizing the hippocampal dentate gyrus involvement in temporal lobe epilepsy  C. Twible
0900-1000 Session 1: Diagnostic Case Presentations
Moderator: Dr. Andrew Gao
0900-0915 Case 1 R. Macaulay
0915-0930 Case 2 S. Kosteniuk
0930-0945 Case 3 R. Zyla
0945-1000 Case 4 B. Joseph
1000-1030 Break
1030-1130 Session 2: Diagnostic Case Presentations
Moderator: Dr. Andrew Gao
1030-1045 Case 5 A. Easton
1045-1100 Case 6 B. Chaharyn
1100-1115 Case 7 H. Li
1115-1130 Case 8 C. Newell
1130-1245 Break
1245-1345 Session 3: Scientific Abstracts: Deep Learning and New Diseases
Moderator: Dr. Peter Schutz
1245-1300 Abstract 14: Deep learning approaches to deciphering intra-tumoural heterogeneity in glioblastoma A. Dent
1300-1315 Abstract 17: COVID-19 pandemic impact on surgical neuropathology services at London Health Sciences Centre S. Pejhan
1315-1335 Abstract 16: Neuropathology of eight cases of the New Brunswick cluster of Neurological Syndrome of Unknown Cause (NSUC) G. Jansen
1335-1350 Abstract 15: Integrating morphologic and molecular histopathological features through whole slide image registration and deep learning M. Lee
1350-1430 Session 4: Neuropathology Practice – Forum
Invited topics for discussion and follow up of neuropathology practice topics from last year.
Moderator: Dr. Peter Gould and Dr. Peter Schutz
0900-0910 Welcome & Introductions and Pre-Test
Moderator: Dr. Peter Gould and Dr. Peter Schutz
0910-1000 David Robertson Invited Lecture:
Evolving classification of epilepsy-associated tumors: Understanding epileptogenesis
Eleonora Aronica, MD PhD
1000-1050 Jerzy Olszewsky Invited Lecture:
Neuropathology in Sudden and Unexpected death in epilepsy and furture directions
SUDEP
Maria Thom, MD
1050-1110 Break
1110-1200 Gordon Mathieson Invited Lecture:
Why are some cerebral malformations more epileptogenic than others? Clues from developmental neuropathology
Epileptogenic mechanisms in cortical malformation.
Harvey Sarnat, MD PhD
1200-1250 Invited Lecture:
Epilepsy as a network disorder
Evolution of surgical concept techniques
George Ibrahim, MD PhD
1250-1320 Post-Test; Resident prizes; Concluding remarks
Moderator: Peter Gould, Peter Schutz

Mary Tom Award

Best Clinical Paper

DR. SUZY KOSTENIUK

Morrison H. Finlayson Award

Best Basic Science

DR. NICOLE SCHWAB

Invited Lecturers

Details on our invited lecturers and presentation materials can be viewed here.

Scientific Abstracts

Abstract #1

Abstract 1- 0900-0915 Category: Clinical At the end of the session,participants will be able to: Identify the presence of this molecular alteration in low grade gliomas Use this important information to correlate it with clinical implications Presenter My name is...

Abstract #2

Abstract 2- 0915-0930 Category: Clinical At the end of the session,participants will be able to: Understand the principal neuropathological feature that distinguishes primitive neuroblastoma from ganglioneuroblastoma Recognize the immunocytochemical neuronal markers...

Abstract #3

Abstract 3- 0930-0945 Category: Clinical At the end of the session,participants will be able to: The diagnosis of malignant astrocytomas based on molecular features of IDH1 mutation may be unaccompanied by year-over-year tumor growth despite no treatment with either...

Abstract #4

Abstract 4- 0945-1000 Category: Clinical At the end of the session,participants will be able to: Optimal utilization of small biopsy specimen is very important in order to facilitate complete molecular work up, from frozen section to making a diagnosis. Specific...

Abstract #5

Abstract 5- 1300-1315 Category: Basic Science At the end of the session,participants will be able to: Introduce a computer-based method for the morphometric evaluation of alpha-synuclein inclusions in Multiple System Atrophy (MSA) brains. Demonstrate variability in...

Abstract #6

Abstract 6- 1315-1330 Category: Clinical At the end of the session,participants will be able to: Understand the relationship between clinical manifestations and neuropathology in AD Describe the characteristics that are associated with cognitive resilience in AD...

Abstract #7

Abstract 7 - 1330-1345 Category: Basic Science At the end of the session,participants will be able to: To understand the basis of abnormal iron accumulation in vulnerable regions of PSP diseased human brains. To understand the patterns of pathological iron...

Abstract #8

Abstract 8- 1345-1400 Category: Basic Science At the end of the session,participants will be able to: To appreciate the value of proteomics in research To understand desmin aggregation in Friedrich cardiomyopathy To understand the cytoskeletal abnormalities in...

Abstract #9

Abstract 9- 1400-1415 Category: Clinical At the end of the session,participants will be able to: tbd  Presenter Dr. Nicole SchwabAuthors Lili-Naz Hazrati (1,2), Nicole Schwab (1,2) (1) The Hospital for Sick Children, Toronto, ON, Canada (2) Department of...

Abstract #10

Abstract 10- 1415-1430 Category: Basic Science At the end of the session,participants will be able to: Mechanisms of astrogliosis involved in the CNS reaction to the neurotrauma in the model of the SCI. Novel interpretation of the role of astrogliosis in histologic...

Diagnostic Case Studies

Case #1

Presentation Time: 0900-0915 Maryam Bintumar1, Sepideh Mokhtari2 and Robert J.B. Macaulay1 1 Department of Pathology, Moffitt Cancer Center, Tampa FL, USA 2 Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL USA  Case 1: Progressive polyneuropathy in...

Case #2

Presentation Time: 0915-0930 Suzy E. Kosteniuk 1, Kristopher D. Langdon 1. Christopher Dunham 2, 3, Sumit Das 4 Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada Division of Anatomic Pathology, British Columbia Children’s...

Case #3

Presentation Time: 0930-0945 Roman E. Zyla1, Brendan C. Dickson1,2, Andrew F. Gao1,3 1. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto ON, Canada 2. Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto ON,...

Case #4

Presentation Time: 0945-1000 B. Joseph MD, J. Maguire MB, BCh, BAO. Division of Neuropathology, Dept. of Pathology and Laboratory Medicine, Vancouver General Hospital, University of British Columbia  Case 4: A Clinical Calamity Presentation: 29 year old female...

Case #5

Presentation Time: 1030-1045 Alexander S. Easton  Department of Pathology, Dalhousie University, Halifax, NS, Canada  Case 5: Acute presentation of an unusual frontal white matter disease This 56 year old black woman, a retired music teacher, presented 13 May...

Case #6

Presentation Time: 1045-1100 Bradley M. Chaharyn and Peter W. Schutz Division of Neuropathology, University of British Columbia, Vancouver, BC  Case 6: Diagnostic case presentation A 45-year-old female presented with a two-year history of slowly progressive...

Case #7

Presentation Time: 1100-1115 Hao Li1, Lee-Cyn Ang1 1Pathology and Laboratory Medicine, London Health Sciences Centre, Schulich School of Medicine and Dentistry, Western University, London ON Canada    Case 7: Diagnostic case presentation 34-year-old male....

Case #8

Presentation Time: 1115-1130 Christopher Newell 1, Gregory A. Kline 2, Jeffrey T. Joseph 1 1 Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada 2 Division of Endocrinology, Department of Medicine, University of Calgary,...

Continuing Professional Development Information

This event is an Accredited Group Learning Activity (Section 1) as defined by the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada, and approved by theCanadian Association of Neuropathologists. You may claim a maximum of 13.25 hours (credits are automatically calculated) 

Through an agreement between the Royal College of Physicians and Surgeons of Canada and the American Medical Association, physicians may convert Royal College MOC credits to AMA PRA Category 1 Credits. Information on the process to convert Royal College MOC credit to AMA credit can be found at www.ama-assn.org/go/internationalcme

In keeping with CMA guidelines, program content and selection of speakers are the responsibility of the program committee. Support is directed towards the costs of the course and not to individual speakers. No commercial support has been solicited for this meeting.