Presentation Time: 0930-0945

Roman E. Zyla1, Brendan C. Dickson1,2, Andrew F. Gao1,3

1. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto ON, Canada 2. Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto ON, Canada 3. Laboratory Medicine Program, University Health Network, Toronto ON, Canada


Case 3: A problematic giant cell-rich lesion of the skull base

A 23 year-old female presented to medical attention with profound loss of vision in the left eye. Her past medical history and family history were otherwise unremarkable. Magnetic resonance imaging (MRI) revealed a 3 cm circumscribed, extra-axial mass centred at the left anterior cranial fossa floor, with heterogeneous T2 signal, homogeneous enhancement and slightly restricted diffusion. There was associated intracranial extension without associated signal abnormality, as well as extension into the nasal cavity and lytic changes of the underlying bone. There was marked compression of the optic nerve.

The patient underwent endoscopic endonasal resection of the tumor, with near-complete return of vision in her left eye.


What is your differential diagnosis for giant cell-rich lesions of the skull base?

What ancillary techniques may be useful in this setting?

Materials submitted:

1. Representative CT and MRI images.
2. One H&E stained slide.

Reveal Diagnosis

To be added after the meeting.