Abstract 7- 0845-0900
Category: Clinical

At the end of the session,
participants will be able to:

  1. Describe the morphological spectrum of ganglioglioma
  2. Clarifying the infiltrative/diffuse variant in ganglioglioma

COI Disclosure:

None to disclose


Dr. Murad Alturkustani is an associate professor in King Abdulaziz University, Jeddah, Saudi Arabia. He is certified by the Royal College of Physician and Surgeons of Canada in both Neuropathology (2012) and Anatomical pathology (2014). He also certified by the American Board of Pathology as Anatomical Pathology (2014) and Pediatric Pathology (2020). His interest is mainly CNS tumors, white matter pathology, and pediatric tumors. He presented many scientific researches in national and international conferences and published many scientific papers in scientific journals 


Murad Alturkustani 1

1 Department of Pathology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

Target Audience:
Pathologists, Residents, Medical Students

Medical Expert (the integrating role), Health Advocate, Scholar, Professional 

Infiltrative pattern in pediatric ganglioglioma


Ganglioglioma is a well-circumscribed low-grade glioneuronal tumor with a broad morphological spectrum. Diffuse glioneuronal tumors are used to describe cases with infiltrative growth. Molecular studies of some of these cases were consistent with ganglioglioma. This work aims to clarify the growth patterns in ganglioglioma. The available slides and clinical and molecular information for ganglioglioma cases under the open pediatric brain tumor atlas from the children’s brain tumor network database were reviewed to confirm the integrated diagnosis and to evaluate the growth patterns in these cases. Infiltration is defined as the presence of neoplastic cells among the nonneoplastic parenchyma. The diagnosis of ganglioglioma was confirmed in 16 of 46 cases (nine females and seven males; age ranges from eight months – 19 years with a mean of 9.9 years). The infiltrative pattern was identified in 5 cases as the predominant pattern and in another 5 cases combined with a circumscribed nodule, while only 6 cases had predominant circumscribed growth. This work confirms the presence of an infiltrative/diffuse variant of ganglioglioma. Awareness of this variant should help with infiltrative tumors, as the differential includes diffuse glioma, which is usually IDH wild type in this population.