2023 Annual Meeting

Date: October 19-21
Location: Montreal QC
October 19 & 20 – Scientific & Clinical Abstract Presentations (McGill Faculty Club)
October 21 – Symposium (The Neuro)

Registration & Banquet Tickets

Earlybird Pricing Ends Sept 1.

Preliminary Goals & Objectives
Scientific Abstract Presentations

Review of current clinical and basic science research pertaining to neuropathology with a focus on Canadian centres, but overall international participation. Also a platform for Canadian residents and trainees to present their recent work.

Diagnostic Case Presentations

Interactive discussion of rare and challenging neuropathological cases encountered by participants in their recent practice. Electronic slides and imaging results are distributed prior to meeting. Often includes case presentation by residents and illustrates advances in disease classification and diagnostic technique.

Overall learning objectives for the meeting

At the end of the meeting participants will:

  1. Describe recent developments in several areas of neuropathology, with particular emphasis on pediatric neuropathology.
  2. Discuss original research and challenging diagnostic cases with colleagues.
  3. Compare the practice of neuropathology on an individual and departmental level across Canadian centres.

Program

President’s Welcome Reception will be Wednesday, October 18th at the McGill Faculty Club.
0730-0800 Registration & Breakfast (Old McGill Room)
0800-8:10 Opening Remarks
Robert Hammond, CANP President
Peter Schutz, CANP Secretary-Treasurer
Billiard Room
0810-0910 Jerzy Olszewsky Invited Lecture
Olszewski, cellular snakes, and the substantia nigra.
John Woulfe, MD, PhD
University of Ottawa
Ottawa, Ontario
0910-1010 Session 1: Scientific Abstract Presentations
Developmental Neuropathology
Moderator:
Sumit Das
Billiard Room
0910-0925 Abstract 1
Aqueductal stenosis and mesencephalosynapsis in fetal brains, part 1: classification, and morphology
Dr. Yael Fisher
0925-0940 Abstract 2
Aqueductal stenosis and mesencephalosynapsis in fetal brains, part 2: associations
Dr. Yael Fisher
0940-0955 Abstract 3
A novel association: distal arthrogryposis, KIF21A and fetal neuroaxonal dystrophy
Dr. Leslie Hamilton
0955-1010 Abstract 4
Polymicrogyria through a tensegrity lens

Dr. Robert Hammond
1010-1030 Break Old McGill Room
1030-1200 Session 2: Scientific Abstract Presentations
Neurodegenerative and Muscle Pathology
Moderator:
Dr. Veronica Hirsch-Reinshagen
Billiard Room
1030-1100 Special Lecture
TMEM106B in neurodegenerative disease and aging
Ian Mackenzie, MD
University of British Columbia Vancouver, British Columbia
1100-1115 Abstract 5
Imaging axonal pathology in the retina as a potential non-invasive biomarker for amyotrophic lateral sclerosis
Farbod Khorrami
1115-1130 Abstract 6
Progressive Supranuclear Palsy: a Novel Phenotype of Germline SQSTM1 (p62) Mutation
Dr. Madison Gray
1130-1145 Abstract 7
A 108 year old brain with near normal cognition
Dr. David Munoz
1145-1200 Abstract 8
Cellular activation patterns of CD10+ fibro-adipogenic progenitors across acquired disease states in human skeletal muscle biopsies
Dr. Peter Schutz
1200-1315 Lunch
(Please make own arrangements, lunch not served)
We suggest:
Timeout Market, 705 rue Sainte-Catherine Ouest, Montreal.
1315-1500 Session 3: Scientific Abstract Presentations
Trauma, vascular, and other
Moderator:
Kristopher D. Langdon, MD PhD FRCPC
Billiard Room
1315-1330 Abstract 9
Assessment challenges and headaches in the implementation of Competence By Design (CBD): The experience in a Diagnostic and Molecular Pathology residency program
Dr. Hao Li
1330-1345 Abstract 10
Isolated small vessel inflammation in temporal artery biopsies: small red flags
Dr. Shervin Pejhan
1345-1400 Abstract 11
The International Spinal Cord Injury Biobank: Neuropathological contributions to global translational research in traumatic spinal cord injury
Dr. Veronica Hirch-Reinshagen
1400-1415 Abstract 12
Death and the MAiD at the Calgary Brain Bank
Dr. Jeffrey Joseph
1415-1430 Abstract 13 WITHDRAWN
Blunt truths: Innovations in identifying neck injuries from infant head trauma
Dr. Evan Matshes
1430-1445 Abstract 14 WITHDRAWN
Eyes or lies? Navigating ocular pathology controversies in infant head trauma
Dr. Evan Matshes
1415-1430 Abstract 15
Pathology of the vertebral artery in medicolegal autopsies
Dr. Fabio Tironi
1530-1930 RCPSC NP Specialty Training Committee Meeting
1530-1800

NEW – Neuropathology Residents’ Workshop: Molecular Investigations for  CNS tumours.

Moderators:
Dr. Leslie Hamilton (Neuropathologist, CHEO and The Ottawa Hospital)
Dr. Shervin Pejhan (Senior Neuropathology Resident, University of Western Ontario)

Learning Objectives

At the end of this workshop, participants will be able to:

  • Provide an overview of different molecular diagnostic techniques for CNS tumours
  • Discuss the practical aspects of ordering molecular testing
  • Describe a general approach for molecular testing of a variety of CNS tumours in pediatric, AYA and adult populations, for diagnosis, therapeutic management and prognostication

Target Audience: Residents, fellows, medical students

CanMeds roles: Medical expert, Collaborator, Leader, Health Advocate, Scholar

1530-1550 Dr. Adrian Levine (Neuropathologist, Hospital for Sick Children)
Molecular testing capabilities for CNS tumours and approach at SickKids
1550-1610 Dr. Romain Cayrol (Neuropathologist, CHU Montreal)
 A practical approach to the molecular diagnosis of CNS tumors
1610-1630 Dr. Sébastien Perreault (Neuro-Oncologist, CHU Ste-Justine)
The Clinical Implications of Molecular Testing for CNS Tumours, with a focus on Pediatric Low Grade Glioma
1630-1645 Break
1645-1745 Case Panel Discussion – CLICK HERE to view the images for review
0730-0815 Breakfast and Registration (Old McGill Room)
0815-0930 Session 4: Scientific Abstracts Presentations
Tumour
Moderator:
Jason Karamchandani, MD
Billiard Room
0815-0830 Abstract 16
Study of gamma-aminobutyric acid and glutamate signaling pathways in glioblastoma
Dr. Raul Cotau
0830-0845 Abstract 17
Using molecular and immunohistochemical features to predict outcomes in grade 3 meningiomas
Dr. Karina Chornenka Martin
0845-0900 Abstract 18
Pediatric-type gliomas in adults: pathologic and molecular features
Dr. Andrew Gao
0900-0915 Abstract 19
Extra-pineal papillary tumor of the pineal region (PTPR) masquarading as a subependymal giant cell tumor (SEGA)
Dr. Kenrick Wysong
0915-0930 Abstract 20
Ethical considerations in the use of DNA methylation profiling for tumor diagnostics
Dr. Kyle Conway
0930-1000 Break Old McGill Room
1000-1130

Neuropathology in Practice Forum: Molecular Testing of Brain Tumors
Moderator: Dr. David Munoz and the Professional Affairs Committee

    • Presentations from leading laboratories and practicing neuropathologists.
    • Discussion of draft of CANP recommendations.
    • Discussion of CANP website as hub for listing laboratories and available molecular tests.

At the end of the session, participants will be able to:

    1. Compare the practice of ordering molecular testing on an individual and departmental level across Canadian centres
    2. Establish contacts across Canada to improve the infrastructure for molecular investigations of brain tumors.
    3. Refer to discussions at the CANP meeting to establish techniques for molecular diagnosis in home departments.

Conflict of Interest statements:

Dr. Del Bigio has a relationship with a for-profit and/or a not-for-profit organization to disclose: Cambridge University Press – book sales royalties (Perinatal Neuropathology)

All other speakers have nothing to disclose.

1130-1245 Lunch
(Please make own arrangements, lunch not served)
We suggest:
Timeout Market, 705 rue Sainte-Catherine Ouest, Montreal.
 
1245-1415 Diagnostic Cases – Session I
Moderator: Dr. Andrew Gao
Billiard Room
1246-1257 Case #1 Dr. Romain Cayrol
1259-1310 Case #2 Dr. Assem Alrumeh
1312-1323 Case #3 Dr. Alexander Easton
1325-1336 Case #4 Dr. Karina Chornenka
1338-1349 Case #5 Dr. Claire Coire
1351-1402 Case #6 Dr. Karam Han
1404-1415 Case #7 Dr. Arnulf Koeppen
1415-1430 Break  Old McGill Room
1430-1600 Diagnostic Cases – Session II
Moderator: Dr. Andrew Gao
Billiard Room
1431-1442 Case #8 Dr. Christother Newell
1444-1455 Case #9 Dr. Shane Eaton
1457-1508 Case #10 Dr. Abdelhakim Khellaf
1510-1521 Case #11 Dr. Benjamin Ellezam
1523-1534 Case #12 Dr. Gabrielle Yeaney
1536-1547 Case #13 Dr. John P. Rossiter
1549-1600 Case #14 Dr. Jacob A. Houpt
1700-1800 Maude Abbott Medical Museum – Osler Collection
Dr. Richard Fraser – guided tour
1800-1830 Bus transport from Maude Abbott Medical Museum to L’Auberge Saint-Gabriel
1830-2130 CANP ANNUAL BANQUET – L’AUBERG SAINT-GABRIEL 
2130 Bus transport from L’Auberg Saint-Gabriel to OMNI Hotel

Presidential Symposium: Pediatric Neuropathology
The Montreal Neurological Institute (The Neuro)
Webster Pavilion/Jeanne Timmins Amphitheatre

Moderators:
Christopher Dunham, MD
Catherine Fallet-Bianco, MD

0700-0800 Bagel breakfast and Registration
0750-0800 Welcome and Pre-Test
0800-0850 Invited Lecture
Topic: Epidemiology and clinical aspects of cerebral palsy in Canada
Maryam Oskoui, MD
McGill University Montreal, Quebec
0850-0940 Gordon Mathieson Lecture
Topic: In utero infections and their effects on the developing brain.
Marc Del Bigio, MD, PhD
University of Manitoba
Winnipeg, Manitoba
0940-1000 Break
1000-1050 David Robertson Lecture
Title: Models And Mechanisms Of Cerebral Cortical Expansion And Folding
David van Essen, PhD
Washington University School of Medicine
St. Louis, Missouri
1050-1140 Invited Lecture
Title: Cerebral Gray Matter Injuries in Infants with Intraventricular Hemorrhage
Praveen Ballabh, MD
Albert Einstein College of Medicine
New York, New York.
1140-1230 Invited Lecture
Title: Cns Manifestations Of Dicer1 Tumor Predisposition Syndrome
William Foulkes, MBBS, PhD
McGill University Montreal, Quebec
1230-1245 Post-Test; Resident prizes; Closing remarks, Adjournment
Moderator: Robert Hammond, Peter Schutz
Printed programs will not be available on site. If you would like a printed copy of the program, abstracts and diagnostic cases, please download and print them below.

Program 2023

Abstracts 2023

Diagnostic Cases2023

Mary Tom Award

Best Clinical Paper

Dr. Karina Chornenka Martin

Using molecular and immunohistochemical features to predict outcomes in grade 3 meningiomas

Morrison H. Finlayson Award

Best Basic Science

Dr. Raul Cotau

Study of gamma-aminobutyric acid and glutamate signaling pathways in glioblastoma

Invited Lecturers

Details on our invited lecturers can be viewed here.

Scientific Abstracts

Abstract #1

Abstract 1- 1010-1025 Category: Clinical At the end of the session, participants will be able to: Describe the morphologic spectrum of aqueductal stenosis Define mesencephalosynapsis and its association with aqueductal lesions and other CNS malformations. COI...

Abstract #2

Abstract 2- 1025-1040 Category: Clinical At the end of the session, participants will be able to: Describe the spectrum of aqueductal stenosis in distinct brain anomalies. Review the presence of the median dorsal glial septum in primary and secondary brain anomalies....

Abstract #3

Abstract 3- 1040-1055 Category: Clinical At the end of the session, participants will be able to: Describe the biologic roles of KIF21A and their linkage to human disease Discuss the association between KIF21A and fetal arthrogryposis Recognize the neuropathological...

Abstract #4

Abstract 4- 1055-1010 Category: Clinical At the end of the session, participants will be able to: To review the pathological features of polymicrogyria, particularly in the setting of congenital CMV encephalitis (CMVE) To consider how the injuries in congenital CMVE...

Abstract #5

Abstract 5- 1100-1115 Category: Basic Science At the end of the session, participants will be able to: Understand the axonal pathology in the retina in ALS. Describe the potential use of different non-invasive eye imaging modalities for assessing ocular biomarkers of...

Abstract #6

Abstract 6- 1115-1130 Category: Clinical At the end of the session, participants will be able to: Appreciate the genetic landscape of familial neurodegenerative disease COI Disclosure: None to disclose.Presenter Madison Gray is currently a PGY5 resident in...

Abstract #7

Abstract 7- 1130-1145 Category: Clinical At the end of the session, participants will be able to: To recognize brain histological changes in the oldest-old To become aware of brain resilience in the oldest-old To explore possible relationships between TDP-43 and...

Abstract #8

Abstract 8- 1145-1200 Category: Basic Science At the end of the session, participants will be able to: Describe the histological appearance and pathological reaction patterns of fibro adipogenic progenitors upon CD10 immunohistochemical staining. List patterns of...

Abstract #9

Abstract 9- 1315-1330 Category: Clinical At the end of the session, participants will be able to: List potential challenges with respect to assessment in Competency by Design (CBD) in Neuropathology residency Describe the reasons for such challenges Propose possible...

Abstract #10

Abstract 10- 1330-1345 Category: Clinical At the end of the session, participants will be able to: Gaining insight into the various subtleties of pathologic features observed in temporal artery biopsies. Understanding the possible clinical and prognostic significance...

Abstract #11

Abstract 11- 1345-1400 Category: Basic Science At the end of the session, participants will be able to: Understand the need for human biospecimens in translational traumatic SCI research. To introduce the International Spinal Cord Injury Biobank, a Canadian resource...

Abstract #12

Abstract 12- 1400-1415 Category: Clinical At the end of the session, participants will be able to: Learn important quality parameters in brain bank tissue Understand that MAiD patients represent an important source of autopsy brain tissue COI Disclosure: None to...

Abstract #13

Abstract 13- 1415-1430 Category: Clinical At the end of the session, participants will be able to: Understand the Connection between Blunt Head Trauma and Neck Injuries in Infants Evaluate Traditional and Advanced Spine Examination Techniques Comprehend the...

Abstract #14

Abstract 14- 1430-1445 Category: Clinical At the end of the session, participants will be able to: Understand the spectrum of ocular pathologies linked to pediatric head trauma Review the underlying theories of ocular pathology frequently documented in infant head...

Abstract #15

Abstract 15- 1445-1500 Category: Clinical At the end of the session, participants will be able to: Understand segmental vulnerability of the vertebral artery to injury and disease under a forensicperspective. Analyze the role of peripheral arteries examination and...

Travel Bursaries

The Canadian Association of Neuropathologists Endowment Trust has established a grant program to assist residents in Neuropathology or other accredited Laboratory Medicine Residency training programs, as well as undergraduate and postgraduate students in Neuroscience, to attend the Annual Meeting of the Association for the purpose of presenting a diagnostic case or delivering an abstract.

The total amount in this award program will be a maximum of $3,000 per year, and the value of each award will be this sum divided by the number of eligible applicants, up to a maximum of $750 per applicant.

This program is intended to supplement existing funding and will only cover expenses not otherwise or only partially reimbursed. Payment of the award will normally be contingent upon submission of original receipts.

To apply, submit a letter from a co-author who is a Member in good standing of the Association describing the nature of the applicant’s participation in the presentation to the Secretary-Treasurer of the CANP.

Deadline to submit is two weeks after the close of the Annual Meeting each year.

Diagnostic Case Studies

Case #1

Presenter Romain CayrolAuthors Romain Cayrol1, Stephanie Wang2, Patrick Benoit3, Abdelhakim Khellaf1, Michael Desjardins3, Kristof Nelson2, Me-Linh Luong3 1Division of Pathology, Department of Clinical Laboratory Medicine, Centre Hospitalier de l’Université de...

Case #2

Presenter Assem S. AlrumehAuthors Assem S. Alrumeh1,2, Cynthia Hawkins1,3, Gelareh Zadeh4, Phedias Diamandis1,2, Andrew F. Gao1,2 1Dept. of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada 2Laboratory Medicine Program, University Health...

Case #3

Presenter Alexander S. EastonAuthors Abigale D. Maclellan1, Gwynedd E. Pickett1,2, Alexander S. Easton1,3 1Faculty of Medicine, 2Division of Neurosurgery, 3Department of Pathology, Dalhousie University, Halifax, Nova Scotia, CanadaClinical Summary This 63 year old...

Case #4

Presenter Karina Chornenka MartinAuthors Karina Chornenka Martin1, Peter W. Schutz1 Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, CanadaClinical Summary A 33-year-old female with past medical history of...

Case #5

Presenter Claire CoireAuthors Claire I. Coire1, David G. Munoz2, Mihaly Kis3 1 Trillium Health Partners, Mississauga Hospital, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto ON Canada. 2 Unity Health Toronto, St. Michael’s Hospital and...

Case #6

Presenter Karam HanAuthors Karam Han 1, Harry V. Vinters 2,3, Shino D. Magaki 2 1 School of Medicine and Public Health, Department of Pathology, University of Wisconsin, Madison, WI 53792, USA 2 Department of Pathology and Laboratory Medicine, David Geffen School of...

Case #7

Presenter Arnulf KoeppenAuthors Arnulf H. Koeppen Research Service, VA Medical Center, Albany, NY12208Clinical Summary A forensic pathologist forwarded the brain of a 56-year-old man who ran a rural tavern in upstate New York. The neuropathological interest arose from...

Case #8

Presenter Christopher NewellAuthors Christopher Newell 1, Katayoon Jafari 1, Kristopher D. Langdon 1, Denise Ng 1 1 Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, CanadaClinical Summary A 26-year-old male presented in January 2020...

Case #9

Presenter Shane EatonAuthors Shane Eaton1, Liesly Lee2, Zachary Feilchenfeld3, Chris Heyn4, Cynthia Hawkins1,5, Julia L. Keith1,6 1 Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada 2 Department of Medicine, Division of Neurology,...

Case #10

Presenter Abdelhakim KhellafAuthors Romain Cayrol1, Abdelhakim Khellaf1, André Lamettti2, 3, Marie-Christine Guiot2, 3, 4, Jason Karamchandani2, 3, 4, José Ferreira5 1Division of Pathology, Department of Clinical Laboratory Medicine, Centre Hospitalier de l’Université...

Case #11

Presenter Benjamin EllezamAuthors Benjamin Ellezam1, Nathalie Langlais2 1Division of Pathology, CHU Sainte-Justine, Montréal, QC, Canada 2Division of Rheumatology, CHR de Lanaudière, St-Charles-Borromée, QC, CanadaClinical Summary A 48-year-old male with a history of...

Case #12

Presenter Gabrielle A. YeaneyAuthors Gabrielle A. Yeaney Division of Neuropathology, Pathology and Lab Medicine Institute, Cleveland Clinic, Cleveland, OHClinical Summary A 58-year-old man with history of a lung mass now has a right cerebellar tumor on imaging.  The...