Christopher Newell


Christopher Newell 1, Katayoon Jafari 1, Kristopher D. Langdon 1, Denise Ng 1

1 Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada

Clinical Summary

A 26-year-old male presented in January 2020 with a 5-day history of nausea, vomiting, and photophobia, who was found to have cranial lesions demonstrating contrast enhancement. Thirty-one months later (August 2022), he presented with a viral illness and anemia, and was found to have innumerable enhancing bony lesions throughout the entire visible axial and appendicular skeleton. Past medical history is significant for a remote resection of a pilocytic astrocytoma of the thoracic spine in Brazil (age 12), and a T2-T12 fusion for scoliosis in Brazil (age 14). A bone marrow biopsy was performed.

Discussion points

  1. What are the major histological findings?
  2. What is the differential diagnosis?
  3. What further investigations are warranted?
Reveal Diagnosis

Case of Metastatic diffuse leptomeningeal glioneuronal tumor