2024 Annual Meeting
October 3-5, 2024
SickKids – Peter Gilgan Centre for Research and Learning
686 Bay Street
Auditorium, 2nd floor
Toronto
Goals & Objectives
Scientific Abstract Presentations
Review of current clinical and basic science research pertaining to neuropathology with a focus on Canadian centres, but overall international participation. Also a platform for Canadian residents and trainees to present their recent work.
Diagnostic Case Presentations
Interactive discussion of rare and challenging neuropathological cases encountered by participants in their recent practice. Electronic slides and imaging results are distributed prior to meeting. Often includes case presentation by residents and illustrates advances in disease classification and diagnostic technique.
Overall learning objectives for the meeting
At the end of the meeting participants will:
- Describe recent developments in several areas of neuropathology with particular emphasis on advances in computational pathology and spatial transcriptomics on neuropathological practice.
- Discuss original research and challenging diagnostic cases with colleagues.
- Reinforce best practices in neuropathology on an individual and departmental level across Canadian centres.
Program
President’s Welcome Reception will be Wednesday, October 2 – 7:00-9:00pm
SickKids Research Tower, 19th Floor.
The program is in development and updates will be posted and circulated as they become available.
- Wednesday, Oct. 2 (1500-2100)
- Thursday, Oct. 3 (0700-1500)
- Friday, Oct. 4 (0700-2100)
- Saturday, Oct. 5 (0700-1245)
| 1500-1800 |
Resident Workshop: Career Exploration in Neuropathology Learning from the diverse career paths, visions, networking, and job-hunting that various staff neuropathologists have experienced – featuring Drs. Adrian Levine, Chris Dunham, Julia Keith, Suzy Kosteniuk, Laura Schmitt, and Marc Del Bigio. 1. To outline the various career paths taken by staff neuropathologists across Canada. 3. To facilitate discussion between trainees and panel members on their unique experiences and career paths (clinical, research, and leadership). The format for this session is informal with ample opportunities for questions and discussion! |
SickKids PSC (patient support centre) Room 11-14-001 |
| 1800-1900 | Break | |
| 1900-2100 | President’s Welcome Reception | SickKids PSC (patient support centre) 22nd Floor – Rooftop Café |
| 0715-0800 | Registration & Breakfast | Gallery – SickKids – Peter Gilgan Centre for Research and Learning, Auditorium, 2nd Floor |
| 0800-815 | Opening Remarks Robert Hammond, CANP President Peter Schutz, CANP Secretary-Treasurer |
SickKids – Peter Gilgan Centre for Research and Learning, Auditorium, 2nd Floor |
| 0815-0915 | Gordon Mathieson Invited Lecture Tauopathies Moderator: Dr. Rob Hammond |
Dr. Gabor Kovacs University of Toronto Toronto, Ontario |
| 0915-0945 | Session 1: Scientific Abstract Presentations Neurodegenerative Moderator: Dr. Rob Hammond |
Peter Gilgan Centre for Research and Learning, Auditorium, 2nd Floor |
| 0915-0930 | Abstract 1 Distinctive pattern of cerebral amyloid angiopathy in the cerebellum |
Dr. David Munoz |
| 0930-0945 | Abstract 2 Nigral astrocytic tau pathology in PSP |
Dr. Hidetomo Tanaka |
| 1015-1045 | Break | Gallery |
| 1045-1145 | Session 2: Scientific Abstract Presentations Neuroscience, Psychiatric, and Other Moderator: Dr. Veronica Hirsch-Reinshagen |
Peter Gilgan Centre for Research and Learning, Auditorium, 2nd Floor |
| 1045-1100 | Abstract 3 Keratan sulfate proteoglycan is expressed in precise temporal and spatial sequences in human fetal forebrain |
Dr. Harvey Sarnat |
| 1100-1115 | Abstract 4 Unique neuropathological mechanisms underlying cognitive impairment in schizophrenia |
Naomi Futhey |
| 1115-1130 | Abstract 5 Recent advances in spatial transcriptomics of the extracellular matrix |
Dr. Erin Stephenson |
| 1130-1330 |
Lunch https://www.google.com/maps/d/edit?mid=1E49Cx8XmQct_Agbzz_mGjkADGJoBtvs&usp=sharing |
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| 1330-1430 | Session 3: Scientific Abstract Presentations Epilepsy and Tumors 1 Moderator: Dr. Cynthia Hawkins |
Peter Gilgan Centre for Research and Learning, Auditorium, 2nd Floor |
| 1330-1345 | Abstract 6 An anatomic transcriptional atlas of focal cortical dysplasia |
Dr. Ameesha Paliwal |
| 1345-1400 | Abstract 7 Transcriptomic profiling reveals hippocampal white matter inflammation as potential epileptogenic focus in temporal lobe epilepsy |
Xuan Wang |
| 1400-1415 | Abstract 8 Global proteomics reveals bidirectional integrin signaling as a driver of glioblastoma invasion |
Dr. Rifat Sajid |
| 1415-1430 | Abstract 9 Integration of molecular and morphometric features improves prognostication of diffuse gliomas |
Dr. Dimitrios Oreopoulos |
| 1530-1930 | RCPSC NP Specialty Training Committee Meeting PGCRL – CRL Event Room 1, 2nd floor |
|
| 0730-0815 | Breakfast and Registration | SickKids – Peter Gilgan Centre for Research and Learning, Auditorium, 2nd Floor (outside the hall) |
| 0815-0915 | Session 4: Scientific Abstracts Presentations Tumors 2 Moderator: Dr. Kristopher Langdon |
Peter Gilgan Centre for Research and Learning, Auditorium, 2nd Floor |
| 0815-0830 | Abstract 10 A 13 year Review of Non-Diffuse Large B Cell Lymphomas of the Central Nervous System at a Tertiary Hospital; a Case Series Study |
Dr. Niloofar Sina |
| 0830-0845 | Abstract 11 Cost-Benefit Analysis of Fluorescence in Situ Hybridization Testing in the Diagnosis of IDH-Mutant 1p/19q-Codeleted Oligodendrogliomas |
Dr. Jacob Houpt |
| 0845-0900 | Abstract 12 Infant-type hemispheric glioma is mostly relatively well-demarcated tumor and not diffusely infiltrative |
Dr. Murad Alturkustani |
| 0900-0915 | Abstract 13 Features of Central Nervous System Metastases by Neoplasms of Gynecological Origin |
Dr. Jacob Houpt |
| 0915-0945 | Break | |
| 0945-1130 | Neuropathology in Practice Forum: Molecular Testing of Brain Tumors Moderator: Dr. Rob Hammond Short presentations: Dr. U. Tabori, University of Toronto: Clinical implications of molecular neuropathology in the genomic era. An oncologist view Dr. M J Lim-Fat, University of Toronto: Clinical Application Of Molecular Testing In Adult Brain Tumors |
|
| 1130-1300 |
Lunch https://www.google.com/maps/d/edit?mid=1E49Cx8XmQct_Agbzz_mGjkADGJoBtvs&usp=sharing |
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| 1300-1415 | Diagnostic Cases – Session I Moderator: Dr. Andrew Gao |
Peter Gilgan Centre for Research and Learning, Auditorium, 2nd Floor |
| 1300-1315 | Case 1 | Dr. Assem Alrumeh |
| 1315-1330 | Case 2 | Dr. Christopher Newell |
| 1330-1345 | Case 3 | Dr. Karina Martin |
| 1345-1400 | Case 4 | Dr. Arnulf Koeppen |
| 1400-1415 | Case 5 | Dr. Shervin Pejhan |
| 1415-1435 | Break | |
| 1435-1535 | Diagnostic Cases – Session II Moderator: Dr. Andrew Gao |
Peter Gilgan Centre for Research and Learning, Auditorium, 2nd Floor |
| 1435-1450 | Case 6 | Dr. Jacob Houpt |
| 1450-1505 | Case 7 | Dr. L. Hamilton |
| 1505-1520 | Case 8 | Dr. M. Khoury |
| 1520-1535 | Case 9 | Dr. Shervin Pejhan |
| 1535-1540 | CANP Announcements | |
| 1700-1800 | Tour of Thomas Fisher Rare Books Library | 120 St George St, Toronto, ON |
| 1800-2100 | CANP ANNUAL BANQUET – UNIVERSITY OF TORONTO FACULTY CLUB 41 Willcocks Street, Toronto |
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Presidential Symposium: Looking to the Future – Digital Pathology and Spatial Transcriptomics Moderators: |
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| 0700-0800 | Breakfast and Registration | SickKids – Peter Gilgan Centre for Research and Learning, Auditorium, 2nd Floor |
| 0750-0800 | Welcome and Pre-Test | |
| 0800-0850 | David Robertson Guest Lecture Topic: Transcriptomic cytoarchitecture of the brain |
Dr. A. Kriegstein UCSF |
| 0850-0940 | Jerzy Olszewski Guest Lecture Topic: An integrated single-cell and spatial transcriptomics approach reveals the heterogeneity of the astrocyte response to stroke |
Dr. M. Faiz University of Toronto |
| 0940-1000 | Break | |
| 1000-1050 | Invited Lecture Title: Digital pathology applications in neurodegeneration |
Dr. Brittany Dugger UC Davis School of Medicine |
| 1050-1140 | Invited Lecture Title: Digital pathology applications in neuro-oncology |
Dr. S. Camelo-Piragua University of Michigan |
| 1140-1230 | Invited Lecture Title: Optimizing Digital Pathology with AI: Strategic Approaches for Modern Clinical Practice |
Dr. Matthew Cecchini Western University |
| 1230-1245 | Post-Test; Resident prizes; Closing remarks, Adjournment Moderator: Robert Hammond, Peter Schutz |
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Printed programs will not be available on site. If you would like a printed copy of the program, abstracts and diagnostic cases, click the PDF links below to download and print them before the meeting.
Presenters without Conflicts of Interest
Assem Alrumeh
Murad Alturkustani
Sumit Das
Peter Gould
Maryam Faiz
Naomi Futhey
Jacob A. Houpt
Kristopher Langdon
Julia Keith
Marc Khoury
Arnulf Koeppen
Karina Martin
David Munoz
Christopher Newell
Dimitrios Oreopoulos
Ameesha Paliwal
Shervin Pejhan
Rifat Sajid
Harvey Sarnat
Peter Schutz
Niloofar Sina
Erin Stephenson
Uri Tabori
Hidetomo Tanaka
Xuan Wang
Presenters with Conflicts of Interest
Sandra Camelo-Piragua
Any direct financial payments including receipt of honoraria:
Name of for-profit or not-for-profit organization(s) : Cambridge University Press
Description of relationship(s) : Book royalties:
All other investments or relationships that could be seen by a reasonable, well- informed participant as having the potential
to influence the content of the educational activity
Name of for-profit or not-for-profit organization(s) : Invenio
Description of relationship(s) : Ad-Hoc Non-paid consultant for image quality analysis
Matthew Cecchini
Any direct financial payments including receipt of honoraria
Name of for-profit or not-for-profit organization(s) : Merck, Astra Zeneca, Roche, Amgen and Eli Lilly
Description of relationship(s) : Speaker Honoria
Membership on advisory boards or speakers’ bureaus
Name of for-profit or not-for-profit organization(s) : Astra Zeneca Eli Lilly
Description of relationship(s) : Ad board for Ki67 and digital pathology
Funded grants or clinical trials
Name of for-profit or not-for-profit organization(s) : Eli Lilly and Merck
Description of relationship(s) : unrestricted research grants for Ki67 implementation and PD-L1 reporting
Patents on a drug, product or device
Name of for-profit or not-for-profit organization(s) : Tenomix
Description of relationship(s) : Partial owner of patent for ultrasound based device to detect lymph nodes in colon
Brittany Dugger
Any direct financial payments including receipt of honoraria
Name of for-profit or not-for-profit organization(s) : University of Southern California
Description of relationship(s) : Alzheimer’s Disease Center External Advisory Board Member
Membership on advisory boards or speakers’ bureaus
Name of for-profit or not-for-profit organization(s) : College of American Pathologists
Description of relationship(s) : Neuropathology Committee member
Funded grants or clinical trials
Name of for-profit or not-for-profit organization(s) : National Institutes of Health
Description of relationship(s) : Principle Investigator/Co-investigator on numerous grants
Andrew Gao
Any direct financial payments including receipt of honoraria
Name of for-profit or not-for-profit organization(s) : Servier Canada
Description of relationship(s) : Speaker Honoraria, Consultancy
Leslie Hamilton
Name of for-profit or not-for-profit organization(s) : National Autopsy Assay Group
Description of relationship(s) : Consultant. Not related to content of my presentation.
Robert Hammond
All other investments or relationships that could be seen by a reasonable, well- informed participant as
having the potential to influence the content of the educational activity
Name of for-profit or not-for-profit organization(s) : MedCBL
Description of relationship(s) : President
Cynthia Hawkins
Any direct financial payments including receipt of honoraria
Name of for-profit or not-for-profit organization(s) : Servier
Description of relationship(s) : honorarium
Membership on advisory boards or speakers’ bureaus
Name of for-profit or not-for-profit organization(s) : The Brain Tumour charity; The Cure Starts Now; ChadTough
Foundation; IronMatt
Description of relationship(s) : SAB
Funded grants or clinical trials
Name of for-profit or not-for-profit organization(s) : CIHR, CCS, OICR
Description of relationship(s) : grants
Veronika Hirsch-Reinshagen
Any direct financial payments including receipt of honoraria
Name of for-profit or not-for-profit organization(s) : Canadian Forensic Medical Consulting
Description of relationship(s) : Consultant
Gabor Kovacs
Any direct financial payments including receipt of honoraria:
Name of for-profit or not-for-profit organization(s) : Parexel
Description of relationship(s) : Advisor/Consultant
Funded grants or clinical trials:
Name of for-profit or not-for-profit organization(s) : Rossy Family Foundation
Description of relationship(s) : Research funding
Patents on a drug, product or device:
Name of for-profit or not-for-profit organization(s) : 5G4 synuclein antibody
Description of relationship(s) : Shared patent
Arnold Kriegstein
Any direct financial payments including receipt of honoraria
Name of for-profit or not-for-profit organization(s) : Neurona Therapeutics
Description of relationship(s) : Consultant, equity holder
Patents on a drug, product or device
Name of for-profit or not-for-profit organization(s) : University of California, San Francisco
Description of relationship(s) : Employee
Mary Jane Lim-Fat
Any direct financial payments including receipt of honoraria
Name of for-profit or not-for-profit organization(s) : Cancer Care Ontario, Servier, Novocure
Description of relationship(s) : Consultancy
Funded grants or clinical trials
Name of for-profit or not-for-profit organization(s) : Brain Cancer Canada, Brain Tumor Foundation of Canada
Description of relationship(s) : Grant
Mary Tom Award
Best Clinical Paper
Dr. Christopher Newell
Morrison H. Finlayson Award
Best Basic Science
Dr. Erin Stephenson
Invited Lecturers
Details on our invited lecturers can be viewed here.
CANP 2024 Sponsorship Prospectus
For sponsorship opportunities, please view the prospectus below.
Contact our Conference Manager for more information.
Scientific Abstracts
2024-Abstract-1
Abstract 1 Category: Basic Science At the end of the session, participants will be able to: To become aware of the difference between progression of amyloid plaques and cerebral amyloid angiopathy when comparing cerebral and cerebellar cortices. To become aware of the...
2024-Abstract 2
Abstract 2 Category: Basic Science At the end of the session, participants will be able to: Describe the details of nigral astrocytic tau pathology in PSP. Compare histopathological findings in the substantia nigra between NITAG and PSP cases. Explore possible...
2024-Abstract 3
Abstract 3 Category: Basic Science At the end of the session, participants will be able to: To appreciate when and where keratan sulfate (KS) appears in the human fetal forebrain and the nature of proteoglycans in general To understand how KS forms a chemical...
2024-Abstract 4
Abstract 4 Category: Basic Science At the end of the session, participants will be able to: Identify the core features of cognitive impairment, including domain-specific measures through targeted clinical testing, in chronic schizophrenia and its prevalence among...
2024-Abstract 5
Abstract 5 Category: Basic Science At the end of the session, participants will be able to: To understand the spectrum of changes of the extracellular matrix in multiple sclerosis and glioblastoma To gain an appreciation for the spatial heterogeneity of extracellular...
2024-Abstract 6
Abstract 6 Category: Basic Science At the end of the session, participants will be able to: Apply deep learning to nominate candidate regions of interest for spatial transcriptomics analysis Identify molecular drivers of excessive excitatory signalling in cellular...
2024-Abstract 7
Abstract 7 Category: Basic Science At the end of the session, participants will be able to: Characterize the spatial transcriptomic landscape of the human hippocampus Identify potential prognostic biomarkers of mesial temporal lobe epilepsy Understand the...
2024-Abstract 8
Abstract 8 Category: Basic Science At the end of the session, participants will be able to: Establish more controlled models of GBM brain invasion. Identify signalling pathways utilized during GBM brain invasion. COI Disclosure: None to disclose.Presenter I am a PhD...
2024-Abstract 9
Abstract 9 Category: Basic Science At the end of the session, participants will be able to: Introduce a platform that enables users to carry out morphometric analysis on digital whole slide images Demonstrate how morphometric features can be integrated with molecular...
2024-Abstract 10
Abstract 10 Category: Clinical At the end of the session, participants will be able to: By the end of this session, participants will be aware of the range of non-diffuse large B-cell lymphomas affecting the CNS, as well as their classifications and main differential...
2024-Abstract 11
Abstract 11 Category: Clinical At the end of the session, participants will be able to: To develop an approach to evaluating diagnostic investigations of diffuse gliomas using a cost-benefitanalysis framework. To compare FISH and NGS in the context of detecting...
2024-Abstract 12
Abstract 12 Category: Clinical At the end of the session, participants will be able to: Recognize the histological and molecular features of infant-type hemispheric glioma (IHG). Differentiate IHG from desmoplastic infantile astrocytoma /ganglioglioma. Differentiate...
2024-Abstract 13
Abstract 13 Category: Clinical At the end of the session, participants will be able to: To review the histopathological features of metastases from gynecological origin. To appreciate the relative abundance of poorly-differentiated and sarcomatoid components...
Travel Bursaries
The Canadian Association of Neuropathologists Endowment Trust has established a grant program to assist residents in Neuropathology or other accredited Laboratory Medicine Residency training programs, as well as undergraduate and postgraduate students in Neuroscience, to attend the Annual Meeting of the Association for the purpose of presenting a diagnostic case or delivering an abstract.
The total amount in this award program will be a maximum of $3,000 per year, and the value of each award will be this sum divided by the number of eligible applicants, up to a maximum of $750 per applicant.
This program is intended to supplement existing funding and will only cover expenses not otherwise or only partially reimbursed. Payment of the award will normally be contingent upon submission of original receipts.
To apply, submit a letter from a co-author who is a Member in good standing of the Association describing the nature of the applicant’s participation in the presentation to the Secretary-Treasurer of the CANP.
Deadline to submit is two weeks after the close of the Annual Meeting each year.
Diagnostic Case Studies
2024-Case 1
Presenter Assem S. AlrumehAuthors Assem S. Alrumeh1,2, Phedias Diamandis1,2, Andrew F. Gao1,2 1Dept. of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada 2Laboratory Medicine Program, University Health Network, Toronto, ON,...
2024-Case 2
Presenter Christopher NewellAuthors Christopher Newell 1 & Christopher Dunham 2,3 1 Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada 2 Division of Anatomic Pathology, British Columbia Children's Hospital, 4500 Oak Street,...
2024-Case 3
Presenter Karina C. MartinAuthors Karina C. Martin1, Stephen Yip1, Ian Mackenzie1 1-Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, CanadaConflict of Interest I do not have a relationship with a...
2024-Case 4
Presenter Arnulf H.KoeppenAuthors Arnulf H. Koeppen, MD, VA Medical Center, Albany, New York, USA and Albany Medical CollegeConflict of Interest I do not have a relationship with a for-profit and/or a not-for-profit organization to disclose.Clinical Summary A...
2024-Case 5
Presenter Shervin PejhanAuthors Shervin Pejhan1, Jeff Terry2, Jon Bush2, Tony Ng3, Christopher Dunham2 1University of Western Ontario 2University of British Columbia, Division of Anatomic Pathology, BC Children’s Hospital (BCCH) 3University of British Columbia,...
2024-Case 6
Presenter Jacob A. HouptAuthors Jacob A. Houpt 1, Hao Li 1, Lee-Cyn Ang 1, David Ramsay 1, Cynthia Hawkins 2, Qi Zhang 1 1 Department of Pathology and Laboratory Medicine, London Health Sciences Centre, London, ON, Canada.2 Hospital for Sick Children, Toronto, ON,...
2024-Case 7
Presenter Leslie E HamiltonAuthors Leslie E Hamilton, MD FRCPC D-ABP Department of Pathology and Laboratory Medicine; University of Ottawa; CHEO and The Ottawa HospitalConflict of Interest I have a relationship with a for-profit and/or a not-for-profit organization to...
2024-Case 8
Presenter Marc KhouryAuthors Marc A. Khoury 1, Julian Spears2, Robert Moreland3, David G. Munoz4 Institute of Medical Science, Division of Neurosurgery, University of Toronto, Division of Neurosurgery, St. Michael’s Hospital, Unity Health Toronto Department of Medical...
2024-Case 9
Presenter Shervin PejhanAuthors Shervin Pejhan1, Ryan Wang2, Sachin Pandey3, Joseph Megyesi2, Claire Coire4, Lee Cyn Ang1,2 1 Department of Pathology & Lab Medicine, Western University, ON, Canada 2 Department of Clinical Neurological Sciences, Western University,...