Thursday, October 23 – 08:15 AM

David Roberston Invited Lecture
Dr. Christopher Power

Christopher Power M.D., F.R.C.P.C is a Professor of Neurology at the University of Alberta, holds the Toupin Chair in in Neurocognitive Disorders and is a Fellow of the Canadian Academy.of Health Sciences. He received a B.Sc. (Hons.) from the University of Toronto and an M.D. from the University of Ottawa and subsequent training in medicine and neurology at McMaster University and the University of Western Ontario, respectively, with postdoctoral fellowships at Johns Hopkins University and the National Institutes of Health in neurovirology. Dr. Power is an internationally recognized clinician-scientist, focused on the causes and potential treatments of neuroinflammatory diseases including NeuroHIV, NeuroCOVID, and multiple sclerosis. Aside from leading the Laboratory for Neurologic Infection and Immunity, he is also an attending neurologist in the University of Alberta HIV and MS Clinics together with Co-Director of the University of Alberta MS Centre. He holds grants from the CIHR, MS Canada, University Hospital Foundation, and is the author of over 250 peer-reviewed publications with an h index of 83.

Title: Pathomechanisms at the interface of neurological infectious and immune disorders

Viral infections of the nervous system remain serious causes of neurological morbidity and mortality. This presentation will concentrate on the clinical and pathogenic aspects of important neurological infections associated with encephalitis including HIV-1, COVID-19, with examples from other relevant neurotropic infections such as monkeypox and pegivirus infections.

Learning Objectives:

  1. tbd

Target audience
Pathologists. Residents

CanMEDS Roles
Communicator, Leader

COI Disclosure:

None to disclose.

 

 

Friday, October 24 – 1330 PM

Neuropathology in Practice Forum Invited Speaker
Dr. Peter Schutz, University of British Columbia

Dr. Peter Schutz is a highly skilled Neuropathologist, specializing in the laboratory diagnosis of disease. Working within the laboratory at a major hospital or diagnostic laboratory in Vancouver, BC, he collaborates closely with clinicians across various specialties.  

He graduated with an MD from Universitaet Wien in 2004 and holds specialty certification as a Neuropathologist. Dr. Schutz also maintains certifications including Certification by the Royal College of Physicians and Surgeons of Canada, underscoring his commitment to professional excellence and continuous education in the field of pathology.


Dr. Benjamin Ellezam, University of Montreal

Dr. Ellezam completed a neuroscience PhD, MD, and anatomic pathology residency at Université de Montréal, followed by a neuropathology fellowship at MD Anderson Cancer Center/Methodist Hospital and Texas Children’s Hospital in Houston. Since 2012, he has served as staff neuropathologist at Sainte-Justine Hospital and associate clinical professor in the Department of Pathology and Cell Biology at Université de Montréal. His practice focuses on neuromuscular pathology, with more than 200 adult and pediatric muscle biopsies reviewed annually, and his research centers on myositis in mixed connective tissue disease.

He founded and directs the Sainte-Justine Biobank for Research on Diseases of the Nervous System, whose scope was recently expanded to include neuromuscular disorders and expected to include over 1,000 muscle biopsy specimens.

Title: Immunohistochemical markers for inflammatory myopathies.

Learning Objectives:

  1. Describe recent developments in muscle biopsy interpretation.
  2. Reinforce best practices in muscle biopsy interpretation across Canadian centres.

Target audience
Pathologists
Residents

CanMEDS Roles
Medical Expert (the integrating role)

COI Disclosure:

None to disclose

Saturday, October 25 – 0800 AM

Gordon Mathieson Lecture
Dr. Ian Mackenzie, University of British Columbia

Ian R. A. Mackenzie is a Professor in the Department of Pathology and Laboratory Medicine at the University of British Columbia and is Head of the Division of Neuropathology at Vancouver General Hospital. Dr. Mackenzie’s research focuses on the neuropathology and genetics of neurodegenerative disease with special interest in the molecular basis of FTD and ALS. He established and is lead investigator of the UBC FTD research program. Major accomplishments include co-PI on studies that identified granulin as a major FTD causing gene, collaborator on research that identified TDP-43 as the pathogenic protein in most cases of FTD and ALS, PI of studies identifying FUS/FET as the pathological protein in most cases of tau/TDP-negative FTD and co-PI on studies that identified mutations in C9orf72 as the most common genetic cause of both ALS and of FTD. He has led an international consortium of neuropathologists which developed a molecular classification system for FTD. He has published more 300 peer-reviewed research papers and 20 book chapters. He has been included on the Thomson Reuters’s list of “Highly Cited Researchers” and “The World’s Most Influential Scientific Minds” since 2014 and he received the 2017 Margolese National Brain Disorders Prize. He is an editorial board member of several international neuroscience journals, is a past President of the Canadian Association of Neuropathology and past Vice President of the formed International Society for Frontotemporal Dementias.

TBC
Experiences with the introduction of competency based medical training in Anatomic Pathology

Description to come

Learning Objectives:

1. TBC
2. TBC
3. TBC

COI Disclosure:

TBC

Get Presentation

Presentation to come

Title: New Approaches to Neurodegenerative Disease Diagnosis and Research

The first part of the presentation will focus on changing concepts of the pathological basis and pathomechanisms of neurodegenerative disease (NDD) and how these impact the way in which NDD autopsies are evaluated and reported. The second portion of the presentation will describe new ways in which neuropathological material can be used in NDD research.

Learning Objectives:

  1. At the end of the session, participants will be able to use modern approaches in the pathological evaluation of neurodegenerative disease autopsies
  2. At the end of the session, participants will be able to apply current methods for the use of neuropathological material in neurodegenerative disease research

Target audience
Pathologists
Residents

CanMEDS Roles
Medical Expert (the integrating role), Communicator, Collaborator, Scholar, Professional

COI Disclosure:

I have a relationship with a for-profit and/or a not-for-profit organization to disclose. Indicate the organization(s) with
which you have/had a relationship over the previous two years and briefly describe the nature of that relationship.
Any direct financial payments including receipt of honoraria
Name of for-profit or not-for-profit organization(s) : Eli Lilly
Description of relationship(s) : paid consultant
Membership on advisory boards or speakers’ bureaus
Name of for-profit or not-for-profit organization(s) : AFTD
Description of relationship(s) : member of grants and research advisory committee
Funded grants or clinical trials
Name of for-profit or not-for-profit organization(s) : NIH, CIHR, Alzheimer Society,
Description of relationship(s) : grant recipient
Patents on a drug, product or device
Name of for-profit or not-for-profit organization(s) : Athena, AviadoBio
Description of relationship(s) : patent holder receiving license payments

Saturday, October 25 – 8:50 AM

Invited Guest Lecture
Dr. Rosa Rademakers, VIB

Dr. Rosa Rademakers received her BSc in Biology (1997) and MSc in Biochemistry (1999) from the University of Antwerp, Belgium, followed by a PhD in 2004. After postdoctoral training at the same institution, she joined the Mayo Clinic in Jacksonville, Florida, in 2005, where she became a full Professor in the Department of Neuroscience in 2014. In 2019, she returned to Belgium as Scientific Director of the VIB-UAntwerp Center for Molecular Neurology and Professor in the Department of Biomedical Sciences at the University of Antwerp.

Her research focuses on the molecular genetics of neurodegenerative diseases, particularly frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). She played a pivotal role in identifying GRN and C9ORF72 as major causal genes in FTD and ALS. Her lab integrates genomic, transcriptomic, epigenomic, and proteomic approaches on brain tissue to uncover disease mechanisms and modifiers. She leads international consortia investigating genetic risk and penetrance in FTD, and has published over 450 peer-reviewed articles. Her contributions have been recognized with the Potamkin Prize, the Sheila Essey Award, and the Paolo Gontijo Medicine Award.

Title: Novel Gene Discovery In Frontotemporal Lobar Degeneration Neuropathological Subtypes

Frontotemporal lobar degeneration (FTLD) encompasses heterogeneous neurodegenerative disorders with distinct neuropathological subtypes defined by protein aggregates (Tau, TDP-43, FUS/TAF15). Each major causal gene (MAPT, GRN, C9orf72) aligns with a specific pathology, suggesting subtype-specific mechanisms. To dissect genetic risk, we established the FTLD-TDP and FTLD-FET consortia, collecting frozen brain tissue from pathologically confirmed cases. In FTLD-TDP, TNIP1 and UNC13A emerged as pan-subtype risk loci, with additional subtype-specific loci identified. Tissue- and cell-type enrichment analyses revealed distinct etiologies across subtypes. In FTLD-FET, a major risk locus at 15q14 was found in ~60% of atypical FTLD-U cases. Long-read sequencing identified a tandem repeat expansion in GOLGA8A, with CT-dimer expansions strongly associating with disease. These findings highlight the importance of neuropathological precision in uncovering genetic risk and disease mechanisms

Learning Objectives:

  1. Understand the relationship between FTLD neuropathological subtypes the associated genetic risk factors
  2. Understand the importance of long-read sequencing in the identification of disease-relevant genetic variants
  3. Appreciate that patients presenting with sporadic disease may carry at least one major genetic risk factor
    contributing to their disease

Target audience
Pathologists, Residents, Medical Students, Other – Write In (Required): basic scientists
CanMEDS Roles
Medical Expert (the integrating role), Scholar, Professional

COI Disclosure:

I have a relationship with a for-profit and/or a not-for-profit organization to disclose. Indicate the organization(s) with which you have/had a relationship over the previous two years and briefly describe the nature of that relationship.
Any direct financial payments including receipt of honoraria
Name of for-profit or not-for-profit organization(s) : Kissick Family Foundation Scientific , Alzheimer Fondation,
Description of relationship(s) : paid member of scientific advisory board
Membership on advisory boards or speakers’ bureaus
Name of for-profit or not-for-profit organization(s) : AFTD, Foundation Alzheimer Research (SAO) Belgium
Description of relationship(s) : non-paid scientific advisory board member
Funded grants or clinical trials
Name of for-profit or not-for-profit organization(s) : Department of defense, NIH, FWO (Flanders research organization)
Description of relationship(s) : provided funding for research

Saturday, October 25 – 10:00 AM

Invited Lecture
Dr. Edward Lee, University of Pennsylvania

Edward B. Lee, M.D., Ph.D., graduated Phi Beta Kappa from Stanford and earned his M.D. and Ph.D. from the University of Pennsylvania. He trained in Anatomic Pathology and Neuropathology before joining Penn’s Department of Pathology and Laboratory Medicine in 2011, where he is now a Professor. He serves as Co-Director of the Institute on Aging, Associate Director of the Penn Alzheimer’s Disease Research Center, and Director of both the CNDR Brain Bank and the Translational Neuropathology Research Lab. His research focuses on Alzheimer’s disease, FTD, ALS, and trauma-related brain injuries. He also continues to serve as a diagnostic neuropathologist at the Hospital of the University of Pennsylvania.

Dr. Lee has made key discoveries, including defining TDP-43 loss in FTD/ALS, identifying vacuolar tauopathy linked to VCP mutations, and pioneering cryo-electron tomography for human brain tissue, authoring over 250 publications. He has received numerous NIH grants and a Clinical Scientist Development Award from the Doris Duke Charitable Foundation. He serves on editorial boards including Acta Neuropathologica, JNEN, Free Neuropathology, Neuropathology and Applied Neurology, and JCI Insight. He is currently the President of AANP, and chairs the NIH study section, CMND. A committed mentor, he has trained 42 researchers, served on over 55 thesis committees, and directs a national NIA-funded workshop for neuropathology trainees. Dr. Lee is dedicated to fostering interdisciplinary collaboration to better understand aging and to develop new therapies for neurodegenerative diseases.

Title: The role of spatially defined omics in understanding the pathophysiology of neurodegenerative diseases.

Post-mortem human brain tissue from individuals with neurodegenerative diseases is often dismissed as “end-stage” and “cross-sectional,” limiting its perceived value for understanding dynamic disease processes. Yet this view overlooks a critical truth: neurodegenerative diseases are slow, relentless, and progressive, meaning that even at autopsy, brain tissue contains a mosaic of cells in varying stages of degeneration. Building on principles of classic human neuropathology, we have developed approaches to analyze post-mortem brain tissue using fluorescence-based sorting techniques and single-cell and single-nucleus sequencing which allow us to resolve distinct cellular populations and states within diseased tissue. These study allow for rich, high-resolution datasets that illuminate the evolving pathophysiology of neurodegeneration, transforming static tissue into a dynamic window on disease progression.

Learning Objectives:

  1. Describe methods to fractionate brain tissue based on pathology
  2. Recall the molecular alterations associated with loss of normal nuclear TDP-43 protein
  3. Combine classic neuropathology methods with emerging spatial omics methods to better understand disease pathophysiology

Target audience
Pathologists, Residents, Medical Students

CanMEDS Roles
Medical Expert (the integrating role), Scholar

COI Disclosure:

I have a relationship with a for-profit and/or a not-for-profit organization to disclose.
Membership on advisory boards or speakers’ bureaus
Name of for-profit or not-for-profit organization(s) : Alnylam, Eli Lilly, Eisai
Description of relationship(s) : Advisory board (unpaid)
Funded grants or clinical trials
Name of for-profit or not-for-profit organization(s) : Alnylam
Description of relationship(s) : Clinical trial (paid to the University of Calgary)

Saturday, October 25 – 10:50 AM

Jerzy Olszewski Invited Lecture
Dr. Eric Smith, University of Calgary

Dr. Eric Smith is Professor of Neurology, Radiology, and Community Health Sciences at the University of Calgary, and the holder of the endowed Katthy Taylor Chair in Vascular Dementia. He directs the Cognitive Neurosciences Clinic at Foothills Medical Centre in Calgary, Alberta, Canada. Dr. Smith is a member of the Steering Committee of the 5th Canadian Consensus Conference on the Diagnosis and Treatment of Dementia, Research Executive Committee of the Canadian Consortium on Neurodegeneration in Aging (ccna-ccnv.ca; Canada’s federally funded national dementia research network), and is a member of the Board of Directors of the Canadian Consortium of Centres for Clinical Cognitive Research (c5r.ca; a national dementia clinical trials network). He has been the site principal investigator (PI)
for numerous trials in Alzheimer’s disease and dementia at the University of Calgary. His investigator-initiated research program seeks to understand vascular contributions to Alzheimer’s disease and dementia through clinical trials, cohort studies, and epidemiological studies on aging, often employing imaging biomarkers. He has more than 600 peerreviewed publications, with an H index of 133 on Google scholar.

Title: Molecular Diagnosis And Treatment Of Alzheimer’s Disease During Life

In the past ten years, Alzheimer’s disease has been reframed clinically as a biological entity based on biomarkers of amyloid, tau, and neurodegeneration. New amyloid targeting therapies remove plaque amyloid effectively, but the clinical benefits are surprisingly modest. Amyloid-related imaging abnormalities, caused by inflammation adjacent to and within amyloid-laden vessels, are the most feared complication of amyloid targeting therapies. This lecture will highlight emerging, practice-changing trends in Alzheimer’s disease diagnosis and treatment that will reshape the interpretation of neuropathology.

Learning Objectives:

  1. Describe methods for testing abeta and tau in plasma
  2. Provide criteria for selecting patients for testing for AD biomarkers
  3. Understand the effect of amyloid targeting therapies on plaque amyloid and vessels

Target audience
Pathologists, Residents, Medical Students

CanMEDS Roles
Medical Expert (the integrating role), Collaborator, Scholar

COI Disclosure:

I have a relationship with a for-profit and/or a not-for-profit organization to disclose.
Membership on advisory boards or speakers’ bureaus
Name of for-profit or not-for-profit organization(s) : Alnylam, Eli Lilly, Eisai
Description of relationship(s) : Advisory board (unpaid)
Funded grants or clinical trials
Name of for-profit or not-for-profit organization(s) : Alnylam
Description of relationship(s) : Clinical trial (paid to the University of Calgary)

Saturday, October 25 – 11:40 AM

Invited Lecture
Dr. Julie Schneider, Rush University

I am The Deborah R. And Edgar D. Jannotta Presidential Professor of Pathology (Neuropathology), and Neurological Sciences at Rush University Medical Center and, and in addition to being the Director, I am the Neuropathology Core Leader of the Rush Religious Orders Study, Clinical Core, and Latino Core which are part of the Rush ADRC grant. I am also the senior neuropathologist of the Rush Memory and Aging Project (MAP) (R01AG017917) and Rush Minority Aging Research Study (MARS) (R01AG022018) since inception. I have been Director of the Rush ADRC since 2022 and was formerly Associate Director.

I am board-certified in both Neurology and Neuropathology, have a Master’s in Clinical Research/Epidemiology and have extensive experience in studies and analyses incorporating neuropathology data and expertise. I have over 500 peer-reviewed publications, 5 book chapters, and have extensive experience collaborating with national and international researchers, on multicenter grants, NIH and foundational workshops, peer-reviews, and partnerships with industry. My research incorporates neuropathology, epidemiology, imaging, biomarkers, and molecular research with a focus on pathologic factors in cognitive decline, mixed pathologies, the role of vascular, LATE pathologies. My current activities specifically focus on inflammation and neurodegeneration in the hippocampus, and leverage neuropathology to advance biomarker development and understanding of risk and mechanisms of neurodegeneration.

Title: Insights of population-based studies into the pathological determinants of dementia

Will present the underlying mixed pathologies of Alzheimer’s and Alzheimer’s related dementia. Teach how there is
preclinical pathologies and resilience to these pathologies, and the role of TDP-43 pathology in aging and memory loss.

Learning Objectives:

  1. Describe the pathologies underlying Alzheimer’s dementia in the community
  2. Understand preclinical dementia and the pathologies in normal older persons
  3. Recognize Limbic-predominate Age-related TDP43 Encephalopathy Neuropatholgic Changes

Target audience
Pathologists, Residents, Medical Students, Other – Write In (Required): Clinicians
CanMEDS Roles
Medical Expert (the integrating role), Communicator, Leader, Scholar, Professional

COI Disclosure:

I do not have a relationship with a for-profit and/or a not-for-profit organization to disclose