Presenter
Claire Coire
Bio
Senior Staff Pathologist/Neuropathologist at Trillium Health Partners since 2002. Graduated from U of T Medical School in 1981; rotating internship at Jewish General hospital; General Pathology residency 1982-1986, Santa Clara Valley Med Centre and McMaster Uni in Hamilton; Neuropathology residency 1987-89 at U of T
Authors
Claire I. Coire1, Cynthia E. Hawkins
1 Trillium Health Partners, Mississauga Hospital, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto ON Canada.
2 Hospital for Sick Children, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto ON Canada
Conflict of Interest
I do not have a relationship with a for-profit and/or a not-for-profit organization to disclose.
Clinical Summary
A 74-year-old female presented to a local hospital with a 2-week history of confusion and left sided weakness. Investigations lead to the discovery of a right extra-axial convexity mass with associated vasogenic edema. Workup for a possible systemic malignancy was negative. She was referred for neurosurgical intervention.
The neurosurgeon’s OR note reads that the tumour was attached to the dura and was located towards the skull base. Complete resection of the tumour was achieved.
Discussion points
- Diagnosis and differential possibilities
- What further immunostain(s) should be done in this case?
- Further workup to arrive at a diagnosis?
Reveal Diagnosis
Extra-axial glioblastoma, IDH-wildtype, CNS WHO grade 4.
Additional relevant investigations and comment:
NGS CNS panel
CNS microarray
DNA methylation
References
1. Glioblastoma Mimicking Meningioma: Report of 2 Cases. World Neurosurg. (2016) 95:624.e9-624.e13
2. Unusual extra-axial high-grade glioma in a young child with Lynch syndrome. BMJ Case Rep 2025;18:e263662.
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