Presenter
Claire Coire
Bio
Staff pathologist and neuropathologist at Trillium Health Partners, Mississauga Hospital since 2002
Authors and Affiliations
Claire I. Coire1, Cynthia E. Hawkins
1 Trillium Health Partners, Mississauga Hospital, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto ON Canada.
2 Hospital for Sick Children, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto ON Canada
Conflict of Interest
I do not have a relationship with a for-profit and/or a not-for-profit organization to disclose.
Clinical Summary
A 43-year-old female presented with a history of progressive headaches, dizziness, falls, and blurry vision over several months. Neuroimaging revealed a large right-sided dural based cystic and solid tumour with associated mass effect and vasogenic edema in the right occipital lobe.
The neurosurgeon achieved subtotal resection of the tumour. His OR note reads that the tumour had well defined borders in some areas; it was attached to the falx and the tentorium on the right side and numerous thrombosed vessels were seen.
Discussion points
- Diagnosis and differential possibilities?
- What further immunostain(s) could be done in this case?
- Relevant workup to arrive at a diagnosis?
Reveal Diagnosis
High Grade Glioma with Pleomorphic and Pseudopapillary Features (HPAP)
Additional relevant investigations and comment.
Infinium DNA Methylation profiling
References (optional)
1. Pratt et al. Acta Neuropathologica (2022) Mar;143(3):403-414.
2. Rossi et al. Acta Neuropathologica Communications (2025) 13:97
3. Goethe et al. Acta Neuropathologica Communications (2025) 13:176
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